When Dr. Hess Green (Stephen Tyrone Williams) is introduced to a mysteriously cursed artifact by an art curator, Lafayette Hightower (Elvis Nolasco), he is uncontrollably drawn into a newfound thirst for blood that overwhelms his soul. He however is not a vampire.
Lafayette quickly succumbs to the ravenous nature of the infliction but leaves Hess a transformed man. Soon Lafayettes wife, Ganja Hightower (Zaraah Abrahams), comes looking for her husband and becomes involved in a dangerous romance with Hess that questions the very nature of love, addiction, sex, and status in our seemingly sophisticated society.
A reinterpretation of Bill Gunns horror cult film Ganja & Hess, which played as a Critics Choice at the 1973 Cannes Film Festival, Spike Lees film was a Kickstarter effort.